I'll add from time to time and maybe others will "get it". I've been taking Pycnogenol since 1995 when I found out about it at a health lecture. We were told MAY prevent cancers. I jumped on it, I was 57. Then along the way I found Grape Seed Extract and found it does about the same thing and half at least the price, so I'm on it about 24 yrs. I take a thyroid support and BP meds and otc pain relief and that's it. I'm 81 soon and stay out of doctors offices as best I can. I'll add later what is profoundly improved in my health.