Yes, that's true. I know I see St. John's wart mentioned a lot with interactions. I've never taken it but think it's used for depression but that one has lots of warnings. Also even spices like cinnamon in large amounts can be harmful. Teens were doing the cinnamon challenge. Don't remember the details but I think they would eat a spoonful for either getting high or something but there were a few deaths. I'll have to look up the reason why they were doing it because I could be wrong but teens usually do these things to get high.